In order to provide a patient with maximal benefits, treatments for stage IV cancer need to be well tolerated and have minimal side effects. Another important requirement is precise targeting tumor and metastases without affection of healthy tissues. Possibility of administration in patients with the poor general condition will be an advantage as well. Among methods that correspond to all the requirements are hyperthermia, active and passive immunotherapy, and chemoembolization. To provide a patient with maximal benefits, treatments for stage…